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Growth Factor Receptor Bound Protein 7 (Grb7)

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B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein

Growth Factor Receptor Bound Protein 7 (Grb7)
CCC F470
HGNC 4567
MGI 102683
PubMed 22005836
RGD 619759
UniProt Q14451
Wiki GRB7
Growth Factor Receptor Bound Protein 7 belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK).
GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF470Hu01 Recombinant Growth Factor Receptor Bound Protein 7 (Grb7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF470Hu01 Polyclonal Antibody to Growth Factor Receptor Bound Protein 7 (Grb7) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Growth Factor Receptor Bound Protein 7 (Grb7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor Receptor Bound Protein 7 (Grb7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF470Mu01 Recombinant Growth Factor Receptor Bound Protein 7 (Grb7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF470Mu01 Polyclonal Antibody to Growth Factor Receptor Bound Protein 7 (Grb7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Growth Factor Receptor Bound Protein 7 (Grb7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor Receptor Bound Protein 7 (Grb7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Factor Receptor Bound Protein 7 (Grb7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Factor Receptor Bound Protein 7 (Grb7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Factor Receptor Bound Protein 7 (Grb7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Factor Receptor Bound Protein 7 (Grb7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Factor Receptor Bound Protein 7 (Grb7) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer."Biochem. Biophys. Res. Commun. 232:5-9(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A novel variant of human Grb7 is associated with invasive esophageal carcinoma."J. Clin. Invest. 102:821-827(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma."Cancer Res. 57:28-31(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3."J. Biol. Chem. 273:7717-7724(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family."FEBS Lett. 467:91-96(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration."J. Biol. Chem. 275:28911-28917(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2."Oncogene 19:2052-2059(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Association of Grb7 with phosphoinositides and its role in the regulation of cell migration."J. Biol. Chem. 277:29069-29077(2002) [PubMed] [Europe PMC] [Abstract]
  12. "EphB1 associates with Grb7 and regulates cell migration."J. Biol. Chem. 277:45655-45661(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Signal transduction via the stem cell factor receptor/c-Kit."Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."Biochem. Biophys. Res. Commun. 337:1-13(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Grb7-SH2 domain dimerisation is affected by a single point mutation."Eur. Biophys. J. 34:454-460(2005) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis."J. Biol. Chem. 284:20215-20226(2009) [PubMed] [Europe PMC] [Abstract]
  18. "The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner."J. Mol. Recognit. 22:9-17(2009) [PubMed] [Europe PMC] [Abstract]
  19. "EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells."J. Biol. Chem. 285:29279-29285(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation."J. Mol. Recognit. 24:314-321(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2."J. Biomol. NMR 27:205-219(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of the RA domain of human GRB7 protein."Submitted (NOV-2004) to the PDB data bank
  23. "Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation."BMC Struct. Biol. 7:58-58(2007) [PubMed] [Europe PMC] [Abstract]