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Histocompatibility HA1, Minor (HMHA1)

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HA-1; HLA-HA1; Minor histocompatibility protein HA-1

Histocompatibility HA1, Minor (HMHA1)
CCC F479
HGNC 17102
MGI 1917969
PubMed 24086303
RGD 1308662
UniProt Q92619
Wiki HMHA1
Cytotoxic T lymphocytes directed against minor histocompatibility antigens of the host were demonstrated in blood from recipients of bone marrow from donors who were genotypically HLA identical. Clones of such cytotoxic T cells were isolated from lymphocyte populations in the blood of patients with severe graft-versus-host disease. The HA-1 antigen is present in 69% of normal people who express HLA-A2, whereas the frequencies of the 3 others in this set of HLA-A2-restricted minor histocompatibility antigens are either high (95% for HA-2); or low (16% of HA-4 and 7% for HA-5). The HLA-1-restricted minor histocompatibility antigen HA-3 occurs in 88% of persons positive for . HA-1, -2, -4, and -5 are inherited independently of the HLA genes; each of them is encoded by a single gene, and none has a locus within the HLA region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF479Hu01 Recombinant Histocompatibility HA1, Minor (HMHA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Histocompatibility HA1, Minor (HMHA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histocompatibility HA1, Minor (HMHA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histocompatibility HA1, Minor (HMHA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histocompatibility HA1, Minor (HMHA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF479Mu01 Recombinant Histocompatibility HA1, Minor (HMHA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF479Mu01 Polyclonal Antibody to Histocompatibility HA1, Minor (HMHA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histocompatibility HA1, Minor (HMHA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histocompatibility HA1, Minor (HMHA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histocompatibility HA1, Minor (HMHA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histocompatibility HA1, Minor (HMHA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histocompatibility HA1, Minor (HMHA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histocompatibility HA1, Minor (HMHA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histocompatibility HA1, Minor (HMHA1) ELISA Kit Customized Service Offer
  1. "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene."Biochem. Biophys. Res. Commun. 278:782-789(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)."Tissue Antigens 56:69-76(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes."BMC Med. Genet. 6:36-36(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism."Science 279:1054-1057(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Minor histocompatibility antigens HA-1-, -2-, and -4-, and HY-specific cytotoxic T-cell clones inhibit human hematopoietic progenitor cell growth by a mechanism that is dependent on direct cell-cell contact."Blood 82:3778-3785(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation."N. Engl. J. Med. 334:281-285(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells."Transpl. Immunol. 4:151-157(1996) [PubMed] [Europe PMC] [Abstract]
  12. "HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation."Transplantation 66:910-916(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells."Transplantation 73:1137-1141(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia."Proc. Natl. Acad. Sci. U.S.A. 100:2742-2747(2003) [PubMed] [Europe PMC] [Abstract]
  15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Definition of the gene encoding the minor histocompatibility antigen HA-1 and typing for HA-1 from genomic DNA."Tissue Antigens 52:305-311(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Therapeutic and diagnostic applications of minor histocompatibility antigen HA-1 and HA-2 disparities in allogeneic hematopoietic stem cell transplantation: a survey of different populations."Biol. Blood Marrow Transplant. 12:95-101(2006) [PubMed] [Europe PMC] [Abstract]