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Recoverin (RCVRN)

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RCV1; Cancer-associated retinopathy protein

Recoverin (RCVRN)
CCC F484
HGNC 9937
MGI 97883
PubMed 17015448
RGD 620258
UniProt P35243
Wiki Recoverin
Recoverin is a 23 kilodalton (kDa) neuronal calcium-binding protein that is primarily detected in the photoreceptors of the eye. It plays a key role in the inhibition of rhodopsin kinase, a molecule which regulates the phosphorylation of rhodopsin. This ultimately controls the ability of the eye to adapt to, and recover from, exposure to the presence of light.The human cDNA clone also showed homology to the calcium-binding chick cone protein, visinin. Analysis of the gene indicated that it is present in single copy and is 9 to 10 kb long with at least 3 exons and 2 introns.The recoverin gene has 3 exons. All 3 EF-hand binding motifs are encoded in the first exon. The arrangement of introns relative to EF-hand calcium binding motifs is unique within the superfamily of EF-hand proteins, suggesting that recoverin defines a new subgroup.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF484Hu01 Recombinant Recoverin (RCVRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF484Hu01 Polyclonal Antibody to Recoverin (RCVRN) WB; IHC; ICC; IP.
Assay Kits SEF484Hu ELISA Kit for Recoverin (RCVRN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Recoverin (RCVRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Recoverin (RCVRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Recoverin (RCVRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Recoverin (RCVRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Recoverin (RCVRN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Recoverin (RCVRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Recoverin (RCVRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Recoverin (RCVRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Recoverin (RCVRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Recoverin (RCVRN) ELISA Kit Customized Service Offer
  1. "Isolation of human retinal genes: recoverin cDNA and gene."Biochem. Biophys. Res. Commun. 187:234-244(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina."Exp. Eye Res. 56:463-470(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The cancer-associated retinopathy antigen is a recoverin-like protein."Invest. Ophthalmol. Vis. Sci. 33:2768-2772(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines."Br. J. Cancer 74:1419-1422(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy."J. Cell Biol. 112:981-989(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of human recoverin at 2.2 A resolution."Submitted (FEB-2007) to the PDB data bank