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Histatin 1 (HTN1)

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PPB; HIS1; Histidine-rich protein 1; Post-PB protein;

Histatin 1 (HTN1)
CCC F487
HGNC 5283
PubMed 2372245
UniProt P15515
Wiki HTN1
Histatin-1 is a phosphoprotein thought to be involved in formation of the acquired enamel pellicle, a proteinaceous layer covering tooth surfaces that forms a barrier between tooth enamel and the oral environment. All 3 major histatins have candidicidal and bactericidal activity.
By Southern analysis of somatic cell hybrids and by in situ hybridization, vanderSpek et al. (1989) demonstrated that the genes for histatins are at a single locus, within 15 kb of each other on chromosome 4, band q13, and that histatin mRNAs are found only in the salivary glands. Two dental disorders, juvenile periodontitis and dentinogenesis imperfecta , map to the same area, as does another salivary protein, statherin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF487Hu01 Recombinant Histatin 1 (HTN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF487Hu01 Polyclonal Antibody to Histatin 1 (HTN1) WB
LAF487Hu71 Biotin-Linked Polyclonal Antibody to Histatin 1 (HTN1) WB; IHC; ICC.
LAF487Hu81 FITC-Linked Polyclonal Antibody to Histatin 1 (HTN1) WB; IHC; ICC; IF.
MAF487Hu21 Monoclonal Antibody to Histatin 1 (HTN1) WB; IHC; ICC; IP.
LAF487Hu72 Biotin-Linked Monoclonal Antibody to Histatin 1 (HTN1) WB; IHC; ICC.
Assay Kits SEF487Hu ELISA Kit for Histatin 1 (HTN1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2)."Biochem. Biophys. Res. Commun. 160:495-502(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family."Mol. Biol. Evol. 10:497-511(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans."J. Biol. Chem. 263:7472-7477(1988) [PubMed] [Europe PMC] [Abstract]
  5. "The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion."J. Biol. Chem. 261:1177-1182(1986) [PubMed] [Europe PMC] [Abstract]
  6. "Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva."Arch. Oral Biol. 35:415-419(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs."Am. J. Hum. Genet. 45:381-387(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland."J. Proteome Res. 6:2472-2480(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Salivary peptidomics."Expert Rev. Proteomics 7:709-721(2010) [PubMed] [Europe PMC] [Abstract]