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Kinesin Family Member 2B belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.MCAK/KIF2 subfamily.Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).
Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1.Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity.
Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1.Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kinesin Family, Member 2B (KIF2B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kinesin Family, Member 2B (KIF2B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kinesin Family, Member 2B (KIF2B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kinesin Family, Member 2B (KIF2B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kinesin Family, Member 2B (KIF2B) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kinesin Family, Member 2B (KIF2B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kinesin Family, Member 2B (KIF2B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kinesin Family, Member 2B (KIF2B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kinesin Family, Member 2B (KIF2B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kinesin Family, Member 2B (KIF2B) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Kinesin Family, Member 2B (KIF2B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Kinesin Family, Member 2B (KIF2B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Kinesin Family, Member 2B (KIF2B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Kinesin Family, Member 2B (KIF2B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kinesin Family, Member 2B (KIF2B) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells."Mol. Biol. Cell 18:2970-2979(2007) [PubMed] [Europe PMC] [Abstract]
- "Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation."Mol. Biol. Cell 23:2264-2274(2012) [PubMed] [Europe PMC] [Abstract]