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Kinesin Family, Member 11 (KIF11)

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Eg5; HKSP; TRIP5; KNSL1; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5

Kinesin Family, Member 11 (KIF11)
CCC F511
HGNC 6388
MGI 1098231
PubMed 23036584
RGD 621258
UniProt P52732
Wiki KIF11
KIF11 encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
Eg5 had the remarkable capability of simultaneously moving at approximately 20 nanometers per second towards the plus ends of each of the 2 microtubules it crosslinked. For antiparallel microtubules, this resulted in relative sliding at approximately 40 nanometers per second, comparable to spindle pole separation rates in vivo. Furthermore, they found that Eg5 can tether microtubule plus ends, suggesting an additional microtubule-binding mode for Eg5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 11 (KIF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 11 (KIF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 11 (KIF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 11 (KIF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 11 (KIF11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 11 (KIF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 11 (KIF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 11 (KIF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 11 (KIF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 11 (KIF11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 11 (KIF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 11 (KIF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 11 (KIF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 11 (KIF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 11 (KIF11) ELISA Kit Customized Service Offer
  1. "Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo."Cell 83:1159-1169(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle."J. Cell Sci. 111:2551-2561(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation."J. Cell Sci. 121:3912-3921(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker."J. Biol. Chem. 276:25496-25502(2001) [PubMed] [Europe PMC] [Abstract]
  15. "A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation."Mol. Cell 27:609-621(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy." Am. J. Hum. Genet. 90:356-362(2012) [PubMed] [Europe PMC] [Abstract]