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Kinesin Family, Member 14 (KIF14)

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Kinesin-like protein KIF14

Kinesin Family, Member 14 (KIF14)
CCC F515
HGNC 19181
MGI 1098226
PubMed 15897902
RGD 1310650
UniProt Q15058
Wiki KIF14
KIF14 is a member of the kinesin superfamily of microtubule-associated motors that play important roles in intracellular transport and cell division .KIF14 protein contains an internal motor domain with a conserved catalytic core, an N-type conserved neck region, a forkhead-associated (FHA) domain, and 4 coiled-coil domains. Immunofluorescence microscopy localized KIF14 throughout the cell cycle in 293T cells and HeLa cells. During interphase, KIF14 localized to the cytoplasm and was redistributed to the nucleus upon entry into mitosis. From prophase to metaphase, KIF14 localized at developing spindle poles and associated microtubules, and during anaphase, KIF14 accumulated at the spindle midzone, where it concentrated during telophase. KIF14 localized to the contractile ring in cells ready to undergo abscission.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF515Hu01 Recombinant Kinesin Family, Member 14 (KIF14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF515Hu21 Monoclonal Antibody to Kinesin Family, Member 14 (KIF14) WB; IHC; ICC; IP.
PAF515Hu01 Polyclonal Antibody to Kinesin Family, Member 14 (KIF14) WB; IHC; ICC; IP.
Assay Kits SEF515Hu ELISA Kit for Kinesin Family, Member 14 (KIF14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 14 (KIF14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 14 (KIF14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 14 (KIF14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 14 (KIF14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 14 (KIF14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 14 (KIF14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 14 (KIF14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 14 (KIF14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 14 (KIF14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 14 (KIF14) ELISA Kit Customized Service Offer
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  6. "KIF14 and citron kinase act together to promote efficient cytokinesis."J. Cell Biol. 172:363-372(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
  8. "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure."Mol. Cell. Biol. 26:3853-3863(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Novel interactors and a role for supervillin in early cytokinesis."Cytoskeleton 67:346-364(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression."J. Cell Biol. 199:951-967(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma."Exp. Mol. Med. 46:E97-E97(2014) [PubMed] [Europe PMC] [Abstract]
  16. "KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer."Neoplasia 16:247-256(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Exome sequencing identifies mutations in KIF14 as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype."Clin. Genet. 86:220-228(2014) [PubMed] [Europe PMC] [Abstract]