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Kinesin Family, Member 22 (KIF22)

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Kid; OBP-1; OBP-2; KNSL4; Kinesin-Like 4; Kinesin-like DNA-binding protein

Kinesin Family, Member 22 (KIF22)
CCC F522
HGNC 6391
MGI 109233
PubMed 22152678
RGD 1311886
UniProt Q14807
Wiki KIF22
KIF22 is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance.The predicted 665-amino acid protein was designated KID. The N-terminal region of KID shares greater than 35% sequence homology with the motor domains of other kinesins. The C-terminal domain has limited but significant homology to NOD. KID also contains a putative nuclear localization signal. the 2.3-kb KID mRNA was expressed in all cancer cell lines tested and in various somatic tissues. In cancer cells, other faint bands were also detected.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 22 (KIF22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 22 (KIF22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 22 (KIF22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 22 (KIF22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 22 (KIF22) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 22 (KIF22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 22 (KIF22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 22 (KIF22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 22 (KIF22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 22 (KIF22) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 22 (KIF22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 22 (KIF22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 22 (KIF22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 22 (KIF22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 22 (KIF22) ELISA Kit Customized Service Offer
  1. "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle."EMBO J. 15:457-467(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2."Genomics 52:374-377(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis."Oncogene 19:5997-6006(2000) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle."Curr. Biol. 18:723-729(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type." Am. J. Hum. Genet. 89:760-766(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of RSGI RUH-070, a C-terminal domain of kinesin-like protein KIF22 from human."Submitted (AUG-2007) to the PDB data bank
  16. "Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity." Am. J. Hum. Genet. 89:767-772(2011) [PubMed] [Europe PMC] [Abstract]
  17. Erratum Am. J. Hum. Genet. 90:170-170(2012)