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Kisspeptin Receptor (KISS1R)

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AXOR12; GPR54; KiSS1-Derived Peptide Receptor; G Protein-Coupled Receptor 54; Hypogonadotropin-1; Kisspeptins receptor; Metastin receptor

Kisspeptin Receptor (KISS1R)
CCC F540
HGNC 4510
MGI 2148793
PubMed 24155777
RGD 70930
UniProt Q969F8
Wiki KISS1R
Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues. Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell.
Kisspeptin is involved in the regulation of endocrine function and the onset of puberty, with activation of the kisspeptin receptor triggering release of gonadotropin-releasing hormone (GnRH), and release of kisspeptin itself being inhibited by oestradiol but enhanced by GnRH. Reductions in kisspeptin levels with age may conversely be one of the reasons behind age-related declines in levels of other endocrine hormones such as luteinizing hormone.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF540Hu01 Recombinant Kisspeptin Receptor (KISS1R) Positive Control; Immunogen; SDS-PAGE; WB.
CPF540Hu21 OVA Conjugated Kisspeptin Receptor (KISS1R) Immunogen; SDS-PAGE; WB.
CPF540Hu22 OVA Conjugated Kisspeptin Receptor (KISS1R) Immunogen; SDS-PAGE; WB.
Antibodies PAF540Hu01 Polyclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
MAF540Hu21 Monoclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
PAF540Hu08 Polyclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
Assay Kits SEF540Hu ELISA Kit for Kisspeptin Receptor (KISS1R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF540Mu01 Recombinant Kisspeptin Receptor (KISS1R) Positive Control; Immunogen; SDS-PAGE; WB.
RPF540Mu02 Recombinant Kisspeptin Receptor (KISS1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF540Mu01 Polyclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
PAF540Mu02 Polyclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
Assay Kits SEF540Mu ELISA Kit for Kisspeptin Receptor (KISS1R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF540Ra01 Recombinant Kisspeptin Receptor (KISS1R) Positive Control; Immunogen; SDS-PAGE; WB.
CPF540Ra21 OVA Conjugated Kisspeptin Receptor (KISS1R) Immunogen; SDS-PAGE; WB.
RPF540Ra02 Recombinant Kisspeptin Receptor (KISS1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF540Ra21 Monoclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
PAF540Ra01 Polyclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
PAF540Ra08 Polyclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
MAF540Ra22 Monoclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
MAF540Ra23 Monoclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
MAF540Ra24 Monoclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
MAF540Ra25 Monoclonal Antibody to Kisspeptin Receptor (KISS1R) WB; IHC; ICC; IP.
Assay Kits SEF540Ra ELISA Kit for Kisspeptin Receptor (KISS1R) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor." Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract]
  2. "FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54."Biochem. Biophys. Res. Commun. 284:1189-1193(2001) [PubMed] [Europe PMC] [Abstract]
  3. "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1." J. Biol. Chem. 276:28969-28975(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The GPR54 gene as a regulator of puberty."N. Engl. J. Med. 349:1614-1627(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "GPR54 and puberty."Trends Endocrinol. Metab. 15:448-453(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Metastin suppresses the motility and growth of CHO cells transfected with its receptor."Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54."Proc. Natl. Acad. Sci. U.S.A. 100:10972-10976(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54."J. Clin. Endocrinol. Metab. 92:1137-1144(2007) [PubMed] [Europe PMC] [Abstract]
  19. "A GPR54-activating mutation in a patient with central precocious puberty."N. Engl. J. Med. 358:709-715(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
  21. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]