Lamin B2 (LMNB2)

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. LMNB2 is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene.The data were consistent with 2 tandemly arranged transcription units, the 3-prime end of one separated by the 5-prime end of the other by a sequence of about 600 bp containing an active promoter.