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Lysyl Oxidase Like Protein 1 (LOXL1)

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LOL; LOXL; Lysyl oxidase homolog 1

Lysyl Oxidase Like Protein 1 (LOXL1)
CCC F551
HGNC 6665
MGI 106096
PubMed 17690259
RGD 1308752
UniProt Q08397
Wiki LOXL1
LOXL1 encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.
The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.Polymorphisms of the gene are associated with the pseudoexfoliation syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF551Hu01 Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF551Hu02 Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF551Hu01 Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC; IP.
PAF551Hu02 Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC; IP.
LAF551Hu71 Biotin-Linked Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC.
LAF551Hu81 FITC-Linked Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC; IF.
MAF551Hu21 Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB,IHC
Assay Kits SEF551Hu ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF551Mu01 Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF551Mu02 Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF551Mu01 Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC; IP.
PAF551Mu02 Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC; IP.
Assay Kits SEF551Mu ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF551Ra01 Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF551Ra01 Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) ELISA Kit Customized Service Offer
  1. "A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25."J. Biol. Chem. 268:18435-18437(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma." Science 317:1397-1400(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people."Hum. Mol. Genet. 17:710-716(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Association of LOXL1 gene with Finnish exfoliation syndrome patients."J. Hum. Genet. 54:289-297(2009) [PubMed] [Europe PMC] [Abstract]