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Vesicle Associated Membrane Protein Associated Protein B (VAPB)

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ALS8; VAMP-B; VAMP-C; VAP-B; VAP-C

Vesicle Associated Membrane Protein Associated Protein B (VAPB)
CCC F569
HGNC 12649
MGI 1928744
PubMed 23446633
RGD 68326
UniProt O95292
Wiki VAPB
VAPB is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
Sequence analysis predicted that the 243-amino acid VAPB protein, which is 60% homologous to VAPA, contains a conserved N-terminal domain, an alpha-helical coiled-coil domain, and a C-terminal transmembrane domain. The 99-amino acid VAPC protein is a splice variant of VAPB that retains the N-terminal 70 residues but lacks the coiled-coil and transmembrane domains. Expression of VAPB was less intense than that of VAPA or the 1.9-kb VAPC transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF569Hu01 Recombinant Vesicle Associated Membrane Protein Associated Protein B (VAPB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF569Hu01 Polyclonal Antibody to Vesicle Associated Membrane Protein Associated Protein B (VAPB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vesicle Associated Membrane Protein Associated Protein B (VAPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vesicle Associated Membrane Protein Associated Protein B (VAPB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vesicle Associated Membrane Protein Associated Protein B (VAPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vesicle Associated Membrane Protein Associated Protein B (VAPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vesicle Associated Membrane Protein Associated Protein B (VAPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vesicle Associated Membrane Protein Associated Protein B (VAPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vesicle Associated Membrane Protein Associated Protein B (VAPB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vesicle Associated Membrane Protein Associated Protein B (VAPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vesicle Associated Membrane Protein Associated Protein B (VAPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vesicle Associated Membrane Protein Associated Protein B (VAPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vesicle Associated Membrane Protein Associated Protein B (VAPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vesicle Associated Membrane Protein Associated Protein B (VAPB) ELISA Kit Customized Service Offer
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  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
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  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B."J. Virol. 79:13473-13482(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)."J. Biol. Chem. 281:30223-30233(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein."J. Biol. Chem. 284:13766-13777(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis."J. Biol. Chem. 285:40266-40281(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis."Hum. Mol. Genet. 21:1299-1311(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis."Am. J. Hum. Genet. 75:822-831(2004) [PubMed] [Europe PMC] [Abstract]