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Vanin 2 (VNN2)

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FOAP-4; GPI-80; Pantetheinase; Vascular Non-inflammatory Molecule 2; Glycosylphosphatidyl inositol-anchored protein GPI-80

Vanin 2 (VNN2)
CCC F570
HGNC 12706
MGI 1347055
PubMed 22374854
UniProt O95498
Wiki VNN2
Vascular non-inflammatory molecule 2 is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF570Hu01 Recombinant Vanin 2 (VNN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF570Hu01 Polyclonal Antibody to Vanin 2 (VNN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vanin 2 (VNN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vanin 2 (VNN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vanin 2 (VNN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vanin 2 (VNN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vanin 2 (VNN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vanin 2 (VNN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vanin 2 (VNN2) ELISA Kit Customized Service Offer
  1. "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."Genomics 53:203-213(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration."J. Immunol. 162:4277-4284(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils."Gene 426:57-64(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."Immunogenetics 53:296-306(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."J. Invest. Dermatol. 129:2167-2174(2009) [PubMed] [Europe PMC] [Abstract]