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Vaccinia Related Kinase 2 (VRK2)

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Serine/threonine-protein kinase VRK2

Vaccinia Related Kinase 2 (VRK2)
CCC F571
HGNC 12719
MGI 1917172
PubMed 21791550
RGD 1311585
UniProt Q86Y07
Wiki VRK2
Serine/threonine-protein kinase VRK2 is an a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas.
Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. While several transcript variants may exist for this gene, the full-length nature of only one has been biologically validated to date.Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF571Hu01 Recombinant Vaccinia Related Kinase 2 (VRK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Vaccinia Related Kinase 2 (VRK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vaccinia Related Kinase 2 (VRK2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF571Hu ELISA Kit for Vaccinia Related Kinase 2 (VRK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF571Mu01 Recombinant Vaccinia Related Kinase 2 (VRK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Vaccinia Related Kinase 2 (VRK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vaccinia Related Kinase 2 (VRK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vaccinia Related Kinase 2 (VRK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vaccinia Related Kinase 2 (VRK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vaccinia Related Kinase 2 (VRK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vaccinia Related Kinase 2 (VRK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vaccinia Related Kinase 2 (VRK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vaccinia Related Kinase 2 (VRK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vaccinia Related Kinase 2 (VRK2) ELISA Kit Customized Service Offer
  1. "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to Vaccinia virus B1R kinase."Genomics 45:327-331(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines."FEBS J. 273:2487-2504(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of three paralogous members of the Mammalian vaccinia related kinase family."J. Biol. Chem. 279:7934-7946(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival."J. Gen. Virol. 87:2869-2878(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus."Mol. Biol. Cell 17:2451-2464(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1."Mol. Cell. Biol. 27:7273-7283(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities."Mol. Cell. Proteomics 7:2199-2214(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."PLoS ONE 3:E1660-E1660(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer."Mol. Cell. Biol. 30:4687-4697(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site."Structure 17:128-138(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]