YY1 Associated Protein 1 (YY1AP1)

YY1AP1 contains the partial promoter and untranslated first exon of ASH1L and coding exons 13 to 21 of GON4L. The 3-prime region of YY1AP1 originated from a long terminal repeat of an endogenous retrovirus, known as the MER51A repeat, that was inserted into exon 21 of GON4L after the duplication.

The deduced YY1AP1 protein contains 750 amino acids, 748 of which correspond to amino acids 590 to 1,337 of the GON4L protein. The last 2 C-terminal residues of YY1AP1 come from the long terminal repeat of MER51A. RT-PCR detected ubiquitous expression of YY1AP1, with highest levels in testis and skeletal muscle. The deduced 467-amino acid protein has a calculated molecular mass of 50.65 kD. The deduced 467-amino acid protein has a calculated molecular mass of 50.65 kD.