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Microfibrillar Associated Protein 1 (MFAP1)

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Microfibrillar Associated Protein 1 (MFAP1)
CCC F587
HGNC 7032
MGI 1914782
PubMed 18765666
RGD 1562232
UniProt P55081
Wiki MFAP1
Microfibrils with a diameter of 10 to 12 nm, found either in association with elastin or independently, are an important component of the extracellular matrix of many tissues. A main component is fibrillin (FBN), a 350-kD protein. FBN1, located on 15q, has been shown to be the site of mutations causing the Marfan syndrome ; FBN2, located on 5q, has been shown to be the site of mutations causing congenital contractural arachnodactyly . Microfibril-associated protein-2 is a 31-kD protein associated with microfibrils.
MFAP1included several splicing factors for which knockdown generates mitotic spindle defects. In addition, a putative nuclear-export terminator was found to speed up cell proliferation and mitotic progression after knockdown.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF587Hu01 Recombinant Microfibrillar Associated Protein 1 (MFAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF587Hu01 Polyclonal Antibody to Microfibrillar Associated Protein 1 (MFAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Microfibrillar Associated Protein 1 (MFAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microfibrillar Associated Protein 1 (MFAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microfibrillar Associated Protein 1 (MFAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microfibrillar Associated Protein 1 (MFAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microfibrillar Associated Protein 1 (MFAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microfibrillar Associated Protein 1 (MFAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microfibrillar Associated Protein 1 (MFAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microfibrillar Associated Protein 1 (MFAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microfibrillar Associated Protein 1 (MFAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microfibrillar Associated Protein 1 (MFAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microfibrillar Associated Protein 1 (MFAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microfibrillar Associated Protein 1 (MFAP1) ELISA Kit Customized Service Offer
  1. "Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21."Genomics 23:443-449(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]