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Myotubularin Related Protein 12 (MTMR12)

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PIP3AP; 3-PAP; 3PAP; Phosphatidylinositol-3-Phosphate Associated Protein; Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit

Myotubularin Related Protein 12 (MTMR12)
CCC F608
HGNC 18191
MGI 2443034
PubMed 23818870
RGD 1307902
UniProt Q9C0I1
Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. MTMR12 functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
3PAP protein has homology to myotubularin but, like SBF1, lacks the HCX5R catalytic motif. Northern blot analysis revealed expression of 5.5- and 2.5-kb 3PAP transcripts that were prominent in brain, heart, kidney, liver, placenta, and lung. Immunoblot analysis showed expression of an 86-kD protein in various tissues and cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myotubularin Related Protein 12 (MTMR12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myotubularin Related Protein 12 (MTMR12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myotubularin Related Protein 12 (MTMR12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myotubularin Related Protein 12 (MTMR12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myotubularin Related Protein 12 (MTMR12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myotubularin Related Protein 12 (MTMR12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myotubularin Related Protein 12 (MTMR12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myotubularin Related Protein 12 (MTMR12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myotubularin Related Protein 12 (MTMR12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myotubularin Related Protein 12 (MTMR12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myotubularin Related Protein 12 (MTMR12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myotubularin Related Protein 12 (MTMR12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myotubularin Related Protein 12 (MTMR12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myotubularin Related Protein 12 (MTMR12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myotubularin Related Protein 12 (MTMR12) ELISA Kit Customized Service Offer
  1. "Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity."Proc. Natl. Acad. Sci. U.S.A. 98:9499-9504(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP."Proc. Natl. Acad. Sci. U.S.A. 100:8660-8665(2003) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]