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Myotubularin Related Protein 5 (MTMR5)

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SBF1; SET Binding Factor 1

Myotubularin Related Protein 5 (MTMR5)
CCC F610
HGNC 10542
MGI 1925230
PubMed 12668758
RGD 1307090
UniProt O95248
By searching an EST database for sequences related to myotubularin (MTM1), Laporte et al. (1998) identified a partial MTMR5 (myotubularin-related protein-5) cDNA and cDNAs encoding 3 other novel members of the myotubularin (MTM) protein family. They noted that the predicted MTMR5 protein lacks catalytically essential residues in the tyrosine phosphatase/DSP active site. The SET (Suvar3-9, Enhancer of zeste, trithorax) domain was originally identified as a characteristic motif in several Drosophila proteins that contribute to epigenetic mechanisms of gene regulation. The human protooncoprotein HRX also contains a SET domain. Using a yeast 2-hybrid assay with the SET domain of HRX as bait, Cui et al. (1998) isolated cDNAs encoding MTMR5, or SBF1 (SET-binding factor-1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myotubularin Related Protein 5 (MTMR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myotubularin Related Protein 5 (MTMR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myotubularin Related Protein 5 (MTMR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myotubularin Related Protein 5 (MTMR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myotubularin Related Protein 5 (MTMR5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myotubularin Related Protein 5 (MTMR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myotubularin Related Protein 5 (MTMR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myotubularin Related Protein 5 (MTMR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myotubularin Related Protein 5 (MTMR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myotubularin Related Protein 5 (MTMR5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myotubularin Related Protein 5 (MTMR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myotubularin Related Protein 5 (MTMR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myotubularin Related Protein 5 (MTMR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myotubularin Related Protein 5 (MTMR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myotubularin Related Protein 5 (MTMR5) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Association of SET domain and myotubularin-related proteins modulates growth control."Nat. Genet. 18:331-337(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human."Hum. Mol. Genet. 7:1703-1712(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9."Mol. Cell. Biol. 20:4900-4909(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "SET binding factor 1 (SBF1) mutation causes Charcot-Marie-Tooth disease type 4B3."Neurology 81:165-173(2013) [PubMed] [Europe PMC] [Abstract]