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Myocyte Specific Enhancer Factor 2C (MEF2C)

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MADS Box Transcription Enhancer Factor 2,Polypeptide C; Myocyte Enhancer Factor 2C

Myocyte Specific Enhancer Factor 2C (MEF2C)
CCC F617
HGNC 6996
MGI 99458
PubMed 23389741
RGD 1563119
UniProt Q06413
Wiki MEF2C
MEF2C is located at 5q14.3 on the minus (Crick) strand and is 200,723 bases in length. The encoded protein has 473 amino acids with a predicted molecular weight of 51.221 kiloDaltons. Three isoforms have been identified. Several post translational modifications have been identified including phosphorylation on serine-59 and serine-396, sumoylation on lysine-391, acetylation on lysine-4 and proteolytic cleavage.
This gene is involved in cardiac morphogenesis and myogenesis and vascular development. It may also be involved in neurogenesis and in the development of cortical architecture. Mice without a functional copy of the Mef2c gene die before birth and have abnormalities in the heart and vascular system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myocyte Specific Enhancer Factor 2C (MEF2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myocyte Specific Enhancer Factor 2C (MEF2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myocyte Specific Enhancer Factor 2C (MEF2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myocyte Specific Enhancer Factor 2C (MEF2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myocyte Specific Enhancer Factor 2C (MEF2C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myocyte Specific Enhancer Factor 2C (MEF2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myocyte Specific Enhancer Factor 2C (MEF2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myocyte Specific Enhancer Factor 2C (MEF2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myocyte Specific Enhancer Factor 2C (MEF2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myocyte Specific Enhancer Factor 2C (MEF2C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myocyte Specific Enhancer Factor 2C (MEF2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myocyte Specific Enhancer Factor 2C (MEF2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myocyte Specific Enhancer Factor 2C (MEF2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myocyte Specific Enhancer Factor 2C (MEF2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myocyte Specific Enhancer Factor 2C (MEF2C) ELISA Kit Customized Service Offer
  1. "MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex."Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993) [PubMed] [Europe PMC] [Abstract]
  2. "hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors."Mol. Cell. Biol. 13:2564-2577(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C."EMBO J. 16:7054-7066(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation."Nature 386:296-299(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes."Mol. Immunol. 35:445-458(1998) [PubMed] [Europe PMC] [Abstract]
  8. "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."Mol. Cell. Biol. 19:7816-7827(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family."J. Biol. Chem. 275:18534-18540(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Cloning and characterization of a histone deacetylase, HDAC9."Proc. Natl. Acad. Sci. U.S.A. 98:10572-10577(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis."Proc. Natl. Acad. Sci. U.S.A. 99:3974-3979(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity."Mol. Cell. Biol. 24:8264-8275(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain."J. Biol. Chem. 280:28749-28760(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors."Mol. Cell. Biol. 25:2273-2287(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation."Mol. Cell. Biol. 25:3575-3582(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity."BMC Biochem. 7:5-5(2006) [PubMed] [Europe PMC] [Abstract]
  18. "MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations."J. Med. Genet. 47:22-29(2010) [PubMed] [Europe PMC] [Abstract]