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Myocyte Specific Enhancer Factor 2D (MEF2D)

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MADS Box Transcription Enhancer Factor 2,Polypeptide D; Myocyte Enhancer Factor 2D

Myocyte Specific Enhancer Factor 2D (MEF2D)
CCC F618
HGNC 6997
MGI 99533
PubMed 22891246
RGD 621489
UniProt Q14814
Wiki MEF2D
Breitbart et al. (1993) obtained MEF2D cDNAs from an adult cardiac ventricle expression library screened at low stringency with a human MEF2B probe. One of the cDNAs encoded a 521-amino acid protein with highly conserved MADS and MEF2 domains. MEF2D occurs as several alternatively spliced transcripts, one of which resembles the Xenopus SRF-related factor SL-1. Unlike the other MEF2 family members, MEF2D is present in undifferentiated myoblasts and may participate in the earliest stages of commitment. Ikeshima et al. (1995) demonstrated strong expression of MEF2D in the cerebellum and cerebrum of developing mouse brains and also in central nervous system neurons of adult mice, suggesting that it may be involved in the differentiation of neurogenic as well as myogenic cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myocyte Specific Enhancer Factor 2D (MEF2D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myocyte Specific Enhancer Factor 2D (MEF2D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myocyte Specific Enhancer Factor 2D (MEF2D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myocyte Specific Enhancer Factor 2D (MEF2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myocyte Specific Enhancer Factor 2D (MEF2D) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myocyte Specific Enhancer Factor 2D (MEF2D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myocyte Specific Enhancer Factor 2D (MEF2D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myocyte Specific Enhancer Factor 2D (MEF2D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myocyte Specific Enhancer Factor 2D (MEF2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myocyte Specific Enhancer Factor 2D (MEF2D) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myocyte Specific Enhancer Factor 2D (MEF2D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myocyte Specific Enhancer Factor 2D (MEF2D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myocyte Specific Enhancer Factor 2D (MEF2D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myocyte Specific Enhancer Factor 2D (MEF2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myocyte Specific Enhancer Factor 2D (MEF2D) ELISA Kit Customized Service Offer
  1. "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage."Development 118:1095-1106(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Regulation of the MEF2 family of transcription factors by p38."Mol. Cell. Biol. 19:21-30(1999) [PubMed] [Europe PMC] [Abstract]
  5. "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."Mol. Cell. Biol. 19:7816-7827(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family."J. Biol. Chem. 275:18534-18540(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Ca(2+)-dependent gene expression mediated by MEF2 transcription factors."J. Biol. Chem. 275:197-209(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis."Proc. Natl. Acad. Sci. U.S.A. 99:3974-3979(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis."Neuron 38:33-46(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain."J. Biol. Chem. 280:28749-28760(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2."J. Neurosci. 25:4823-4834(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors."Mol. Cell. Biol. 25:2273-2287(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications."Mol. Cell. Biol. 25:8456-8464(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation."Mol. Cell. Biol. 25:3575-3582(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation."J. Biol. Chem. 281:4423-4433(2006) [PubMed] [Europe PMC] [Abstract]
  16. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]