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Oxysterol Binding Protein Like Protein 11 (OSBPL11)

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ORP11; OSBP12

Oxysterol Binding Protein Like Protein 11 (OSBPL11)
CCC F630
HGNC 16397
MGI 2146553
PubMed 8619474
RGD 1307294
UniProt Q9BXB4
Wiki OSBPL11
Oxysterol-binding protein-related protein 11 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.
Sequence analysis predicted that the 747-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 amino acids that includes the OSBP motif (EQVSHHPP). It has a pleckstrin homology (PH) domain in its N terminus. OSBPL11 is 75% and 58% identical to OSBPL10 in the SB and PH domains, respectively. Gene expression database analysis indicated highest expression in lung and spleen, followed by brain, liver, and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 11 (OSBPL11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 11 (OSBPL11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 11 (OSBPL11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 11 (OSBPL11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 11 (OSBPL11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 11 (OSBPL11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 11 (OSBPL11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 11 (OSBPL11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 11 (OSBPL11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 11 (OSBPL11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 11 (OSBPL11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 11 (OSBPL11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 11 (OSBPL11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 11 (OSBPL11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 11 (OSBPL11) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The OSBP-related protein family in humans."J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface."Exp. Cell Res. 316:3304-3316(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the PH domain of oxysterol binding protein-related protein 11 from human."Submitted (JUN-2006) to the PDB data bank
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]