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Phosphodiesterase 4A, cAMP Specific (PDE4A)

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DPDE2; PDE46; Dunce(Drosophila)-Homolog Phosphodiesterase E2; cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Phosphodiesterase 4A, cAMP Specific (PDE4A)
CCC F641
HGNC 8780
MGI 99558
PubMed 21898905
RGD 3279
UniProt P27815
Wiki PDE4A
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction.
PDE4A is a class IV cAMP-specific PDE . The major transcript encodes a deduced 779-amino acid protein with 2 N-terminal domains that share a high degree of conservation with other DPDE proteins, and a C-terminal catalytic domain. Northern blot analysis detected a 4.5-kb DPDE2 transcript in normal human temporal cortex. RNase protection assays showed that DPDE2 was expressed in 6 of 7 cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 4A, cAMP Specific (PDE4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 4A, cAMP Specific (PDE4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 4A, cAMP Specific (PDE4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 4A, cAMP Specific (PDE4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 4A, cAMP Specific (PDE4A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 4A, cAMP Specific (PDE4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 4A, cAMP Specific (PDE4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 4A, cAMP Specific (PDE4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 4A, cAMP Specific (PDE4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 4A, cAMP Specific (PDE4A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 4A, cAMP Specific (PDE4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 4A, cAMP Specific (PDE4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 4A, cAMP Specific (PDE4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 4A, cAMP Specific (PDE4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 4A, cAMP Specific (PDE4A) ELISA Kit Customized Service Offer
  1. "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs."Mol. Cell. Biol. 13:6558-6571(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)."Cell. Signal. 6:793-812(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19."Biochem. J. 308:683-691(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2."Biochem. J. 333:693-703(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10."Mol. Pharmacol. 59:996-1011(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene."Mol. Pharmacol. 67:1920-1934(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change."Biochem. J. 411:361-369(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase."Mol. Cell. Biol. 10:2678-2686(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Purification and characterization of the human pde4a catalytic domain (pde4a(330-723)) expressed in sf9 cells."Arch. Biochem. Biophys. 394:54-60(2001) [PubMed] [Europe PMC] [Abstract]
  12. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK."Biochem. J. 428:55-65(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors."Biochem. J. 408:193-201(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone."Submitted (JUL-2009) to the PDB data bank