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Phosphodiesterase 5A, cGMP Specific (PDE5A)

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CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase

Phosphodiesterase 5A, cGMP Specific (PDE5A)
CCC F645
HGNC 8784
MGI 2651499
PubMed 21215707
RGD 620995
UniProt O76074
Wiki PDE5A
PDE5A encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.
The predicted 875-amino acid human protein is approximately 96% identical to bovine PDE5A. Like the bovine protein, human PDE5A contains a cGMP-binding domain in its N-terminal portion and a catalytic domain in its C-terminal region. Recombinant PDE5A protein hydrolyzed cGMP in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF645Hu01 Recombinant Phosphodiesterase 5A, cGMP Specific (PDE5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF645Hu01 Polyclonal Antibody to Phosphodiesterase 5A, cGMP Specific (PDE5A) WB; IHC; ICC; IP.
MAF645Hu21 Monoclonal Antibody to Phosphodiesterase 5A, cGMP Specific (PDE5A) WB; IHC; ICC; IP.
Assay Kits SEF645Hu ELISA Kit for Phosphodiesterase 5A, cGMP Specific (PDE5A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 5A, cGMP Specific (PDE5A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 5A, cGMP Specific (PDE5A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 5A, cGMP Specific (PDE5A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 5A, cGMP Specific (PDE5A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 5A, cGMP Specific (PDE5A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 5A, cGMP Specific (PDE5A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 5A, cGMP Specific (PDE5A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 5A, cGMP Specific (PDE5A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 5A, cGMP Specific (PDE5A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 5A, cGMP Specific (PDE5A) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase."Gene 216:139-147(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene."Eur. J. Biochem. 255:391-399(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase."Biochem. Biophys. Res. Commun. 247:249-254(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells."Invest. Ophthalmol. Vis. Sci. 40:1745-1752(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells."J. Biol. Chem. 277:3310-3317(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules."Nature 425:98-102(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease."Nature 519:472-476(2015) [PubMed] [Europe PMC] [Abstract]