≡

Phosphodiesterase 6D, cGMP Specific (PDE6D)

[Edit]

PDED; Protein p17; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Phosphodiesterase 6D, cGMP Specific (PDE6D)
CCC F649
HGNC 8788
MGI 1270843
PubMed 23150559
RGD 1306204
UniProt O43924
Wiki PDE6D
cGMP is the cellular second messenger involved in the transduction of visual signals in retinal rod and cone cells. Constitutively synthesized by guanylate cyclase, its level is tightly controlled by modulating its degradation by a specific phosphodiesterase (cGMP-PDE). The enzyme characterized from bovine retinal rod cells is made of a catalytic core consisting of a membrane-associated alpha-beta dimer. An inhibitory gamma subunit enables transducin to regulate the rate of cGMP degradation according to incoming visual signals. The delta subunit (PDE6D) seems to play a role in stabilizing the catalytic dimer from membranes.Amino acid analysis predicted that the putative mammalian protein is soluble and acidic, contains 2 N-linked glycosylation sites, and lacks hydrophobic transmembrane domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 6D, cGMP Specific (PDE6D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 6D, cGMP Specific (PDE6D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 6D, cGMP Specific (PDE6D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 6D, cGMP Specific (PDE6D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 6D, cGMP Specific (PDE6D) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 6D, cGMP Specific (PDE6D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 6D, cGMP Specific (PDE6D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 6D, cGMP Specific (PDE6D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 6D, cGMP Specific (PDE6D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 6D, cGMP Specific (PDE6D) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 6D, cGMP Specific (PDE6D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 6D, cGMP Specific (PDE6D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 6D, cGMP Specific (PDE6D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 6D, cGMP Specific (PDE6D) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 6D, cGMP Specific (PDE6D) ELISA Kit Customized Service Offer
  1. "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene."Genomics 49:76-82(1998) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36."Cytogenet. Cell Genet. 79:139-141(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse."Eur. J. Hum. Genet. 6:283-290(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes."J. Biol. Chem. 273:22340-22345(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner."FEBS Lett. 458:55-59(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase."Proc. Natl. Acad. Sci. U.S.A. 96:1315-1320(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium." Hum. Mutat. 35:137-146(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The complex of Arl2-GTP and PDE delta: from structure to function."EMBO J. 21:2095-2106(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo."Nat. Chem. Biol. 7:942-949(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo."EMBO Rep. 14:465-472(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling."Nature 497:638-642(2013) [PubMed] [Europe PMC] [Abstract]