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Nebulette (NEBL)

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LNEBL; Actin-binding Z-disk protein

Nebulette (NEBL)
CCC F662
HGNC 16932
MGI 1921353
PubMed 20951326
UniProt O76041
Wiki Nebulette
Nebulette is an isoform of the protein nebulin. While nebulin (600-900 kDa) is expressed preferentially in skeletal muscle, nebulette (107 kDa) is expressed in cardiac muscle.
Nebulette was identified in 1995 by Moncman and Wang using primary cultures of chicken embryonic cardiomyocytes by immunoprecipitations with certain anti-nebulin monoclonal antibodies. Normal expression of nebulette is essential for the assembly and contractile function of myofibrils.
Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Binds to actin and plays an important role in the assembly of the Z-disk.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF662Hu01 Recombinant Nebulette (NEBL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Nebulette (NEBL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nebulette (NEBL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nebulette (NEBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nebulette (NEBL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nebulette (NEBL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nebulette (NEBL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nebulette (NEBL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nebulette (NEBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nebulette (NEBL) ELISA Kit Customized Service Offer
  1. "Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs."J. Mol. Biol. 282:111-123(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Functional dissection of nebulette demonstrates actin binding of nebulin-like repeats and Z-line targeting of SH3 and linker domains."Cell Motil. Cytoskeleton 44:1-22(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1."J. Biol. Chem. 279:20401-20410(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy."Hum. Genet. 107:440-451(2000) [PubMed] [Europe PMC] [Abstract]