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N-Myristoyltransferase 1 (NMT1)

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Myristoyl-CoA:protein N-myristoyltransferase 1; Glycylpeptide N-tetradecanoyltransferase 1

N-Myristoyltransferase 1 (NMT1)
CCC F673
HGNC 7857
MGI 102579
PubMed 2358444
RGD 628642
UniProt P30419
Wiki NMT1
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1). Insertional mutagenesis of the Nmt1 gene in Saccharomyces cerevisiae causes recessive lethality, indicating that N-myristoylation provides an essential function for one or more of the approximately 12 proteins of this yeast that are substrates for Nmt1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF673Hu01 Recombinant N-Myristoyltransferase 1 (NMT1) Positive Control; Immunogen; SDS-PAGE; WB.
APF673Hu01 Active N-Myristoyltransferase 1 (NMT1) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to N-Myristoyltransferase 1 (NMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Myristoyltransferase 1 (NMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Myristoyltransferase 1 (NMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Myristoyltransferase 1 (NMT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Myristoyltransferase 1 (NMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Myristoyltransferase 1 (NMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Myristoyltransferase 1 (NMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Myristoyltransferase 1 (NMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Myristoyltransferase 1 (NMT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Myristoyltransferase 1 (NMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Myristoyltransferase 1 (NMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Myristoyltransferase 1 (NMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Myristoyltransferase 1 (NMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Myristoyltransferase 1 (NMT1) ELISA Kit Customized Service Offer
  1. "Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction."J. Biol. Chem. 272:28680-28689(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A second mammalian N-myristoyltransferase."J. Biol. Chem. 273:6595-6598(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae."Proc. Natl. Acad. Sci. U.S.A. 89:4129-4133(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme."Biochem. J. 333:491-495(1998) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055."Submitted (SEP-2009) to the PDB data bank
  15. "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells."Nat. Commun. 5:4919-4919(2014) [PubMed] [Europe PMC] [Abstract]