≡

2',5'-Oligoadenylate Synthetase 3 (OAS3)

[Edit]

p100OAS

2',5'-Oligoadenylate Synthetase 3 (OAS3)
CCC F690
HGNC 8088
MGI 2180850
PubMed 19056102
UniProt Q9Y6K5
Wiki OAS3
2'-5'-oligoadenylate synthetase 3 is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
The domains share 44 to 60% protein sequence similarity with each other and 42 to 60% sequence identity with the conserved domain of OAS1. The authors noted that OAS1, OAS2, and OAS3 contain 1, 2, and 3 conserved OAS domains or units, respectively. Northern blot analysis revealed that OAS3 is expressed as a 7-kb interferon-induced mRNA in HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF690Hu01 Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF690Hu01 Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3) WB; IHC; ICC; IP.
MAF690Hu21 Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3) WB; IHC; ICC; IP.
Assay Kits SEF690Hu ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 2',5'-Oligoadenylate Synthetase 3 (OAS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 2',5'-Oligoadenylate Synthetase 3 (OAS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for 2',5'-Oligoadenylate Synthetase 3 (OAS3) ELISA Kit Customized Service Offer
  1. "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains."J. Biol. Chem. 274:1557-1565(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular basis of T cell-mediated recognition of pancreatic cancer cells."Cancer Res. 61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase."Genomics 70:232-240(2000) [PubMed] [Europe PMC] [Abstract]