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Oxysterol Binding Protein Like Protein 1A (OSBPL1A)

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ORP1; ORP-1; OSBPL1B; OSBP8; Oxysterol-Binding Protein-Related Protein 1

Oxysterol Binding Protein Like Protein 1A (OSBPL1A)
CCC F697
HGNC 16398
MGI 1927551
PubMed 21999571
UniProt Q9BXW6
Wiki OSBPL1A
Oxysterol-binding protein-related protein 1 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. ORP1 encodes a deduced 437-amino acid protein. Yeast complementation assays indicated that ORP1 is a counterpart of yeast Kes1. Fluorescence microscopy demonstrated expression of ORP1 in the cytosol.
Endogenous expression in a neuroblastoma cell line was upregulated by exposure to low density lipoprotein. Similar treatment on a hepatocellular carcinoma cell line did not result in significant alterations in ORP1 mRNA levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 1A (OSBPL1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 1A (OSBPL1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 1A (OSBPL1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 1A (OSBPL1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 1A (OSBPL1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 1A (OSBPL1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 1A (OSBPL1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 1A (OSBPL1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 1A (OSBPL1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 1A (OSBPL1A) ELISA Kit Customized Service Offer
  1. "A family of 12 human genes containing oxysterol-binding domains."Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport."J. Biol. Chem. 276:18407-18414(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The OSBP-related protein family in humans."J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments."Mol. Biol. Cell 16:5480-5492(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]