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Oxysterol Binding Protein Like Protein 8 (OSBPL8)

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ORP8; OSBP10; Oxysterol-Binding Protein-Related Protein 8

Oxysterol Binding Protein Like Protein 8 (OSBPL8)
CCC F701
HGNC 16396
MGI 2443807
PubMed 1735225
RGD 1561474
UniProt Q9BZF1
Wiki OSBPL8
OSBPL8 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.The deduced 488-amino acid protein was predicted to be 33% identical to mouse Osbp. RT-PCR analysis detected wide expression that was strongest in testis, ovary, liver, kidney, and brain. Within brain, expression was particularly strong in caudate nucleus.Sequence analysis predicted that the 847-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF701Hu01 Recombinant Oxysterol Binding Protein Like Protein 8 (OSBPL8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF701Hu21 Monoclonal Antibody to Oxysterol Binding Protein Like Protein 8 (OSBPL8) WB; IHC; ICC; IP.
PAF701Hu01 Polyclonal Antibody to Oxysterol Binding Protein Like Protein 8 (OSBPL8) WB; IHC; ICC; IP.
Assay Kits SEF701Hu ELISA Kit for Oxysterol Binding Protein Like Protein 8 (OSBPL8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 8 (OSBPL8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 8 (OSBPL8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 8 (OSBPL8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 8 (OSBPL8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 8 (OSBPL8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxysterol Binding Protein Like Protein 8 (OSBPL8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxysterol Binding Protein Like Protein 8 (OSBPL8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxysterol Binding Protein Like Protein 8 (OSBPL8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxysterol Binding Protein Like Protein 8 (OSBPL8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxysterol Binding Protein Like Protein 8 (OSBPL8) ELISA Kit Customized Service Offer
  1. "A family of 12 human genes containing oxysterol-binding domains."Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The OSBP-related protein family in humans."J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (KIAA1451 protein)."Submitted (JUN-2004) to the PDB data bank