≡

Peptidyl Arginine Deiminase Type IV (PADI4)

[Edit]

PAD; PADI5; PDI4; PDI5; Peptidyl Arginine Deiminase Type V; Peptidylarginine deiminase IV

Peptidyl Arginine Deiminase Type IV (PADI4)
CCC F709
HGNC 18368
MGI 1338898
PubMed 21655091
RGD 3290
UniProt Q9UM07
Wiki PADI4
PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
The deduced 663-amino acid protein, approximately 50% identical to rat PAD types I, II, and III and 73% identical with rat keratinocyte PAD IV, is most conserved in the C terminal two-thirds of the sequence. Functional analysis indicated that the recombinant protein is fully active against arginine-containing substrates. Western blot analysis showed that expression of a 67-kD protein is induced by incubation of HL60 cells with differentiation factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF709Hu01 Recombinant Peptidyl Arginine Deiminase Type IV (PADI4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF709Hu01 Polyclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB; IHC; ICC; IP.
MAF709Hu21 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB
MAF709Hu22 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB; IHC; ICC; IP.
MAF709Hu23 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB; IHC; ICC; IP.
MAF709Hu24 Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) WB; IHC; ICC; IP.
Assay Kits SEF709Hu ELISA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidyl Arginine Deiminase Type IV (PADI4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidyl Arginine Deiminase Type IV (PADI4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidyl Arginine Deiminase Type IV (PADI4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidyl Arginine Deiminase Type IV (PADI4) ELISA Kit Customized Service Offer
  1. "Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)."J. Biol. Chem. 274:27786-27792(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Immunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils."J. Leukoc. Biol. 70:46-51(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis." Nat. Genet. 34:395-402(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Histone deimination antagonizes arginine methylation."Cell 118:545-553(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human PAD4 regulates histone arginine methylation levels via demethylimination."Science 306:279-283(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Comparison of enzymatic properties between hPADI2 and hPADI4."Biochem. Biophys. Res. Commun. 327:192-200(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination."Proc. Natl. Acad. Sci. U.S.A. 102:3611-3616(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Histone deimination as a response to inflammatory stimuli in neutrophils."J. Immunol. 180:1895-1902(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation."Arthritis Rheum. 62:1630-1640(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for Ca(2+)-induced activation of human PAD4."Nat. Struct. Mol. Biol. 11:777-783(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4."Proc. Natl. Acad. Sci. U.S.A. 103:5291-5296(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization."Biochemistry 45:11727-11736(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene."Acta Crystallogr. D 67:112-118(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The development of N-alpha-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors."J. Med. Chem. 54:6919-6935(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors."ACS Chem. Biol. 7:160-165(2012) [PubMed] [Europe PMC] [Abstract]
  20. "High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2-4 by a novel haplotype-specific sequencing-based approach."J. Mol. Med. 82:762-767(2004) [PubMed] [Europe PMC] [Abstract]