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Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2)

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GRB4; NCKbeta; Growth factor receptor-bound protein 4; NCK adaptor protein 2; SH2/SH3 adaptor protein NCK-beta

Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2)
CCC F711
HGNC 7665
MGI 1306821
PubMed 24287595
RGD 1305965
UniProt O43639
Wiki NCK2
NCK belongs to family of adaptor proteins,There are two mammalian NCK genes.NCK1 and NCK2. NCK2 is also known as NCKBeta/Grb4. NCK/NCK1/NCKalpha, which is located in chromosome 3 and NCK2 is located in chromosome 2 respectively.
NCK adaptor protein 2 contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 2 (NCK2) ELISA Kit Customized Service Offer
  1. "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity."J. Biol. Chem. 273:25171-25178(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways."Mol. Biol. Cell 9:3367-3382(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck."J. Biol. Chem. 274:5542-5549(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling."J. Cell Biol. 145:851-863(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and kinetic analysis of the interaction between Nck-2 and DOCK180."FEBS Lett. 491:193-199(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1."FEBS Lett. 580:15-22(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress."J. Biol. Chem. 281:26633-26644(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the SH3 domain of the human cytoplasmic protein NCK2."Submitted (JUL-2005) to the PDB data bank