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Pantothenate Kinase 2 (PANK2)

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HSS; HARP; NBIA1; PKAN; Hallervorden-Spatz Syndrome; Neurodegeneration With Brain Iron Accumulation 1; Pantothenic acid kinase 2

Pantothenate Kinase 2 (PANK2)
CCC F712
HGNC 15894
MGI 1921700
PubMed 22983956
UniProt Q9BZ23
Wiki PANK2
Pantothenate kinase 2, mitochondrial is a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells.
It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF712Hu01 Recombinant Pantothenate Kinase 2 (PANK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 2 (PANK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 2 (PANK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 2 (PANK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 2 (PANK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF712Mu01 Recombinant Pantothenate Kinase 2 (PANK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 2 (PANK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 2 (PANK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 2 (PANK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 2 (PANK2) ELISA Kit Customized Service Offer
  1. "An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria."Hum. Mol. Genet. 12:321-327(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome."Nat. Genet. 28:345-349(2001) [PubMed] [Europe PMC] [Abstract]
  6. "HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration."Neurology 58:1673-1674(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome."N. Engl. J. Med. 348:33-40(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Atypical Hallervorden-Spatz disease with preserved cognition and obtrusive obsessions and compulsions."Mov. Disord. 20:880-886(2005) [PubMed] [Europe PMC] [Abstract]