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Pantothenate Kinase 3 (PANK3)

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Pantothenic acid kinase 3

Pantothenate Kinase 3 (PANK3)
CCC F713
HGNC 19365
MGI 2387464
PubMed 17631502
RGD 1310531
UniProt Q9H999
PANK3 encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver.
Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine.PANK3 is expressed most abundantly in the liver. The human PANK3 gene resides on chromosome 5q35.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pantothenate Kinase 3 (PANK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 3 (PANK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 3 (PANK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 3 (PANK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 3 (PANK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pantothenate Kinase 3 (PANK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 3 (PANK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 3 (PANK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 3 (PANK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 3 (PANK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pantothenate Kinase 3 (PANK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pantothenate Kinase 3 (PANK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pantothenate Kinase 3 (PANK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pantothenate Kinase 3 (PANK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pantothenate Kinase 3 (PANK3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome."Nat. Genet. 28:345-349(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder."J. Biol. Chem. 282:27984-27993(2007) [PubMed] [Europe PMC] [Abstract]