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Polymerase DNA Directed Beta (POLb)

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Polymerase DNA Directed Beta (POLb)
CCC F721
HGNC 9174
MGI 97740
PubMed 2261080
RGD 3363
UniProt P06746
Wiki POLB
DNA polymerase beta maintains genome integrity by participating in base excision repair. Over expression of POLB mRNA has been correlated with a number of cancer types whereas deficiencies in POLB results in hypersensitivity to alkylating agents, induced apoptosis and chromosomal breaking therefore it is essential that POLB expression is tightly regulated.
POLB gene is upregulated by CREB1 transcription factor binding to the cAMP response element(CRE) present in the promoter of the POLB gene in response to exposure to alkylating agents. POLB gene expression is also regulated at the post transcriptional level as the 3’UTR of the POLB mRNA has been shown to contain three stem-loop structures that influence gene expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF721Hu01 Recombinant Polymerase DNA Directed Beta (POLb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF721Hu01 Polyclonal Antibody to Polymerase DNA Directed Beta (POLb) WB; IHC; ICC; IP.
MAF721Hu21 Monoclonal Antibody to Polymerase DNA Directed Beta (POLb) WB; IHC; ICC; IP.
Assay Kits SEF721Hu ELISA Kit for Polymerase DNA Directed Beta (POLb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Beta (POLb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Beta (POLb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Beta (POLb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Beta (POLb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Beta (POLb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase DNA Directed Beta (POLb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase DNA Directed Beta (POLb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase DNA Directed Beta (POLb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Beta (POLb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Beta (POLb) ELISA Kit Customized Service Offer
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  10. "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups."Biochemistry 37:6456-6464(1998) [PubMed] [Europe PMC] [Abstract]
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  18. "Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential."Structure 11:121-127(2003) [PubMed] [Europe PMC] [Abstract]