Peroxiredoxin 4 (PRDX4)
[Edit]Antioxidant enzyme AOE372; Thioredoxin-dependent peroxide reductase A0372
-95754.jpg)
Peroxiredoxin-4 is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules.
This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.Sequence analysis predicted that the 271-amino acid protein, 70% identical to a yeast thiol-specific antioxidant, contains a signal peptide and 2 peroxide catalysis cysteine motifs conserved in all human peroxiredoxins. Functional analysis showed that PRDX4 protects glutamine synthetase (GLUL) from inactivation.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF754Hu01 | Recombinant Peroxiredoxin 4 (PRDX4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPF754Hu02 | Recombinant Peroxiredoxin 4 (PRDX4) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAF754Hu01 | Polyclonal Antibody to Peroxiredoxin 4 (PRDX4) | WB; IHC; ICC; IP. |
| MAF754Hu21 | Monoclonal Antibody to Peroxiredoxin 4 (PRDX4) | WB; IHC; ICC; IP. | |
| PAF754Hu02 | Polyclonal Antibody to Peroxiredoxin 4 (PRDX4) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF754Hu | ELISA Kit for Peroxiredoxin 4 (PRDX4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF754Mu01 | Recombinant Peroxiredoxin 4 (PRDX4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPF754Mu02 | Recombinant Peroxiredoxin 4 (PRDX4) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAF754Mu01 | Polyclonal Antibody to Peroxiredoxin 4 (PRDX4) | WB; IHC; ICC; IP. |
| LAF754Mu71 | Biotin-Linked Polyclonal Antibody to Peroxiredoxin 4 (PRDX4) | WB; IHC; ICC. | |
| PAF754Mu02 | Polyclonal Antibody to Peroxiredoxin 4 (PRDX4) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF754Mu | ELISA Kit for Peroxiredoxin 4 (PRDX4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Peroxiredoxin 4 (PRDX4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Peroxiredoxin 4 (PRDX4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Peroxiredoxin 4 (PRDX4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Peroxiredoxin 4 (PRDX4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Peroxiredoxin 4 (PRDX4) | ELISA Kit Customized Service Offer |
- "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation."J. Biol. Chem. 272:30952-30961(1997) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
- , Submitted (DEC-2008) to UniProtKB
- "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress."Biochem. J. 366:777-785(2002) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]