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Phosphorylase Kinase Alpha 2 (PHKa2)

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PHK; PYK; PYKL; XLG; XLG2; Phosphorylase b kinase regulatory subunit alpha, liver isoform

Phosphorylase Kinase Alpha 2 (PHKa2)
CCC F761
HGNC 8926
MGI 97577
PubMed 10330341
RGD 1596945
UniProt P46019
Wiki PHKA2
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by PHKa2. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphorylase Kinase Alpha 2 (PHKa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphorylase Kinase Alpha 2 (PHKa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphorylase Kinase Alpha 2 (PHKa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphorylase Kinase Alpha 2 (PHKa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphorylase Kinase Alpha 2 (PHKa2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphorylase Kinase Alpha 2 (PHKa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphorylase Kinase Alpha 2 (PHKa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphorylase Kinase Alpha 2 (PHKa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphorylase Kinase Alpha 2 (PHKa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphorylase Kinase Alpha 2 (PHKa2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphorylase Kinase Alpha 2 (PHKa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphorylase Kinase Alpha 2 (PHKa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphorylase Kinase Alpha 2 (PHKa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphorylase Kinase Alpha 2 (PHKa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphorylase Kinase Alpha 2 (PHKa2) ELISA Kit Customized Service Offer
  1. "X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit."Am. J. Hum. Genet. 56:381-387(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of cDNA encoding the human liver phosphorylase kinase alpha subunit (PHKA2) and identification of a missense mutation of the PHKA2 gene in a family with liver phosphorylase kinase deficiency."Biochem. Mol. Biol. Int. 36:505-511(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete genomic structure and mutational spectrum of PHKA2 in patients with X-linked liver glycogenosis type I and II."Am. J. Hum. Genet. 64:1541-1549(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Variability of biochemical and clinical phenotype in X-linked liver glycogenosis with mutations in the phosphorylase kinase PHKA2 gene."Hum. Genet. 102:423-429(1998) [PubMed] [Europe PMC] [Abstract]
  8. "X-linked liver glycogenosis: localization and isolation of a candidate gene."Hum. Mol. Genet. 2:583-589(1993) [PubMed] [Europe PMC] [Abstract]
  9. "The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution."J. Biol. Chem. 268:23208-23214(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase."Hum. Mol. Genet. 5:649-652(1996) [PubMed] [Europe PMC] [Abstract]
  18. "Mutation hotspots in the PHKA2 gene in X-linked liver glycogenosis due to phosphorylase kinase deficiency with atypical activity in blood cells (XLG2)."Hum. Mol. Genet. 5:653-658(1996) [PubMed] [Europe PMC] [Abstract]
  19. "Glycogen storage disease type IX: High variability in clinical phenotype."Mol. Genet. Metab. 92:88-99(2007) [PubMed] [Europe PMC] [Abstract]