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Retinoic Acid Induced Protein 1 (RAI1)

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SMCR; SMS

Retinoic Acid Induced Protein 1 (RAI1)
CCC F767
HGNC 9834
MGI 103291
RGD 1308500
UniProt Q7Z5J4
RAI1 is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. RAI1 has no potential membrane-spanning hydrophobic domains. Northern blot analysis revealed expression of several transcripts. An 8-kb transcript was expressed in all adult and fetal tissues and brain regions examined, except fetal liver. A 10-kb transcript was expressed weakly in heart, kidney, pancreas, stomach, thyroid, spinal cord, and lymph node. A 1.5-kb transcript was detected only in placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Induced Protein 1 (RAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Induced Protein 1 (RAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Induced Protein 1 (RAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Induced Protein 1 (RAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Induced Protein 1 (RAI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Induced Protein 1 (RAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Induced Protein 1 (RAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Induced Protein 1 (RAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Induced Protein 1 (RAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Induced Protein 1 (RAI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Induced Protein 1 (RAI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Induced Protein 1 (RAI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Induced Protein 1 (RAI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Induced Protein 1 (RAI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Induced Protein 1 (RAI1) ELISA Kit Customized Service Offer
  1. "RAI1 is a novel polyglutamine encoding gene that is deleted in Smith-Magenis syndrome patients."Gene 270:69-76(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia."Genomics 82:162-171(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in RAI1 associated with Smith-Magenis syndrome."Nat. Genet. 33:466-468(2003) [PubMed] [Europe PMC] [Abstract]
  7. "CAG repeat length in RAI1 is associated with age at onset variability in spinocerebellar ataxia type 2 (SCA2)."Hum. Mol. Genet. 9:1753-1758(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity."Am. J. Hum. Genet. 90:941-949(2012) [PubMed] [Europe PMC] [Abstract]