≡

Retinoblastoma Binding Protein 5 (RBBP5)

[Edit]

RBQ3; SWD1; Retinoblastoma-binding protein RBQ-3

Retinoblastoma Binding Protein 5 (RBBP5)
CCC F768
HGNC 9888
MGI 1918367
PubMed 22231628
RGD 1305532
UniProt Q15291
Wiki RBBP5
Retinoblastoma-binding protein 5 is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.The total nucleotide sequence of 1 of these clones, RBBP5, which the aurhors designated RBQ3, was found to encode a protein of 66 kD localized in the nucleus. RBBP5 protein preferentially binds to underphosphorylated RB protein. The region used for binding to this protein was mapped to the E1A-binding pocket B of pRB, which has sequence similarity to the general transcription factor TFIIB .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 5 (RBBP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 5 (RBBP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 5 (RBBP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 5 (RBBP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 5 (RBBP5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 5 (RBBP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 5 (RBBP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 5 (RBBP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 5 (RBBP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 5 (RBBP5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 5 (RBBP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 5 (RBBP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 5 (RBBP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 5 (RBBP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 5 (RBBP5) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping."Genomics 27:511-519(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus."Mol. Cell 13:587-597(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  8. "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex."J. Biol. Chem. 280:41725-41731(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
  11. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation."J. Biol. Chem. 284:7542-7552(2009) [PubMed] [Europe PMC] [Abstract]
  15. "On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex."J. Biol. Chem. 284:24242-24256(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation."Cell 151:1097-1112(2012) [PubMed] [Europe PMC] [Abstract]