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Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1)

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LCA11; IMPD; RP10; IMPD1

Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1)
CCC F776
HGNC 6052
MGI 96567
PubMed 11875049
RGD 1311108
UniProt P20839
Wiki IMPDH1
IMP dehydrogenase 1 acts as a homotetramer to regulate cell growth. IMPDH1 is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides.
The sequence of these clones demonstrated an open reading frame for a protein containing 514 amino acids. The molecular mass of the produced protein was 56 kD, which is the observed molecular mass of the purified protein and of the immunoprecipitated in vitro translation product. A high order of conservation of the IMP dehydrogenase protein was indicated by the finding that human and Chinese hamster cDNA clones differed by only 8 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inosine-5'-Monophosphate Dehydrogenase 1 (IMPDH1) ELISA Kit Customized Service Offer
  1. "Two distinct cDNAs for human IMP dehydrogenase."J. Biol. Chem. 265:5292-5295(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of human type I and type II IMP dehydrogenases."J. Biol. Chem. 268:27286-27290(1993) [PubMed] [Europe PMC] [Abstract]
  7. "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding."Biochem. Pharmacol. 49:1323-1329(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo."Biochem. J. 379:243-251(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the human type I inosine monophosphate dehydrogenase and implications for isoform specificity."Submitted (FEB-2009) to the PDB data bank
  12. "Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice."Hum. Mol. Genet. 11:547-557(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa."Hum. Mol. Genet. 11:559-568(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and Leber congenital amaurosis."Invest. Ophthalmol. Vis. Sci. 47:34-42(2006) [PubMed] [Europe PMC] [Abstract]