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Ribophorin II (RPN2)

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RIBIIR; RPN-II; RPNII; SWP1; Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit 2; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa

Ribophorin II (RPN2)
CCC F780
HGNC 10382
MGI 98085
PubMed 18724378
RGD 62075
UniProt P04844
Wiki RPN2
RPN2 encodes a type I integral ribophorin membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. The cDNA clones hybridized to mRNA species of 2.5 kb and encoded polypeptides of 68.5 and 69.3 kD, respectively. Sequence comparisons and immunoblotting with specific antibodies showed both proteins to be highly conserved throughout a variety of species. However, no relationship between the 2 proteins could be deduced from their primary sequences.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribophorin II (RPN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribophorin II (RPN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribophorin II (RPN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribophorin II (RPN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribophorin II (RPN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribophorin II (RPN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribophorin II (RPN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribophorin II (RPN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribophorin II (RPN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribophorin II (RPN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribophorin II (RPN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribophorin II (RPN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribophorin II (RPN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribophorin II (RPN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribophorin II (RPN2) ELISA Kit Customized Service Offer
  1. "Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins."EMBO J. 6:75-82(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits."Biochemistry 44:5982-5992(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."J. Biol. Chem. 286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]