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Clavesin 2 (CLVS2)

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C6orf212; C6orf213; RLBP1L2; Retinaldehyde Binding Protein 1-Like 2

Clavesin 2 (CLVS2)
CCC F782
HGNC 23046
MGI 2443223
RGD 1306801
UniProt Q5SYC1
CLVS2 binding to PtdIns(3,5)P2 is not required for localization. Required for normal morphology of late endosomes and/or lysosomes in neurons By similarity. Binds phosphatidylinositol 3,5-bisphosphate.
Forms a complex with clathrin heavy chain and gamma-adaptin.
RT-PCR analysis of 18 human tissues showed expression of RLBP1L1 exclusively in brain. Transfection experiments with an EGFP-RLBP1L1 fusion construct in HeLa cells showed localization to the cytoplasm where the RLBP1 protein localizes.Kong et al. (2006) determined that RLBP1L1 contains 6 exons and spans about 212 kb.By sequence analysis, Kong et al. (2006) mapped the RLBP1L1 gene to chromosome 8q12.2 between D8S1225 and RH12812 STS markers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clavesin 2 (CLVS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clavesin 2 (CLVS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clavesin 2 (CLVS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clavesin 2 (CLVS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clavesin 2 (CLVS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clavesin 2 (CLVS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clavesin 2 (CLVS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clavesin 2 (CLVS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clavesin 2 (CLVS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clavesin 2 (CLVS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Clavesin 2 (CLVS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Clavesin 2 (CLVS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Clavesin 2 (CLVS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Clavesin 2 (CLVS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Clavesin 2 (CLVS2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology."J. Biol. Chem. 284:27646-27654(2009) [PubMed] [Europe PMC] [Abstract]