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Hepsin (HPN)

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TMPRSS1; Transmembrane Protease,Serine 1

Hepsin (HPN)
CCC F801
HGNC 5155
MGI 1196620
PubMed 19911255
RGD 61982
UniProt P05981
Wiki Hepsin
Hepsin encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain.
This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.It is present in the plasma membrane in a molecular orientation of type II membrane-associated proteins, with its catalytic subunit (C-terminal half) at the cell surface and its N terminus facing the cytosol. Hepsin is not found in cytosol. See also TMPRSS2, a related serine protease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepsin (HPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepsin (HPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepsin (HPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepsin (HPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepsin (HPN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepsin (HPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepsin (HPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepsin (HPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepsin (HPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepsin (HPN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepsin (HPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepsin (HPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepsin (HPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepsin (HPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepsin (HPN) ELISA Kit Customized Service Offer
  1. "A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells."Biochemistry 27:1067-1074(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization."J. Biol. Chem. 266:16948-16953(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth."Proc. Natl. Acad. Sci. U.S.A. 90:7181-7185(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Proteolytic activation of pro-macrophage-stimulating protein by hepsin."Mol. Cancer Res. 9:1175-1186(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers."Biochem. J. 390:125-136(2005) [PubMed] [Europe PMC] [Abstract]