≡

Anoctamin 8 (ANO8)

[Edit]

TMEM16H; Transmembrane Protein 16H

Anoctamin 8 (ANO8)
CCC F815
HGNC 29329
MGI 2687327
PubMed 20964844
UniProt Q9HCE9
By searching databases for sequences similar to TMEM16E, Katoh and Katoh (2005) identified the TMEM16H gene.The deduced full-length protein contains 1,232 amino acids. They identified a splice variant that contains an 823-bp insertion corresponding to a retained intron 17 and that results in a C-terminally truncated protein of 1,114 amino acids due to an in-frame stop codon in intron 17. Both full-length TMEM16H and its splice variant contain the 8 transmembrane domains and N and C termini facing the cytoplasm that are characteristic of all TMEM16 family members.
Katoh and Katoh (2005) detected TMEM16H expression in embryonic stem cells, fetal brain, and neural tissues.expression in all adult tissues and all specific brain regions examined, with highest expression in the cerebellum and substantia nigra.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 8 (ANO8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 8 (ANO8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 8 (ANO8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 8 (ANO8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 8 (ANO8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 8 (ANO8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 8 (ANO8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 8 (ANO8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 8 (ANO8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 8 (ANO8) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of TMEM16H gene in silico."Int. J. Mol. Med. 15:353-358(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  7. "CFTR and TMEM16A are separate but functionally related Cl-channels."Cell. Physiol. Biochem. 28:715-724(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Anoctamins are a family of Ca2+ activated Cl- channels."J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]