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Tensin 2 (TNS2)

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TENC1; C1-TEN; C1TEN; TNS2; Tensin Like C1 Domain Containing Phosphatase; C1 domain-containing phosphatase and tensin homolog

Tensin 2 (TNS2)
CCC F818
HGNC 19737
MGI 2387586
PubMed 23095816
RGD 1310917
UniProt Q63HR2
Tensin 2belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
The N termini of both proteins contain an actin-binding domain and a PTEN homology region. The C termini contain SH2 domains and the phosphotyrosine-binding domain. Northern blot analysis revealed a 5.0-kb transcript expressed predominantly in heart, skeletal muscle, kidney, and liver. Expression in brain, colon, thymus, and peripheral blood leukocytes was extremely low.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tensin 2 (TNS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tensin 2 (TNS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tensin 2 (TNS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tensin 2 (TNS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tensin 2 (TNS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tensin 2 (TNS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tensin 2 (TNS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tensin 2 (TNS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tensin 2 (TNS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tensin 2 (TNS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tensin 2 (TNS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tensin 2 (TNS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tensin 2 (TNS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tensin 2 (TNS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tensin 2 (TNS2) ELISA Kit Customized Service Offer
  1. "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration."Proc. Natl. Acad. Sci. U.S.A. 99:733-738(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration."FASEB J. 19:971-973(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2."Biochim. Biophys. Acta 1823:199-205(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the PTB domain of KIAA1075 protein from human."Submitted (OCT-2006) to the PDB data bank