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Trafficking Protein Particle Complex 9 (TRAPPC9)

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IKBKBBP; NIBP; T1; TRS120; TRAPP 120 kDa Subunit; Tularik Gene 1; NIK-and IKBKB-binding protein

Trafficking Protein Particle Complex 9 (TRAPPC9)
CCC F825
HGNC 30832
MGI 1923760
PubMed 22279557
RGD 1309461
UniProt Q96Q05
NIBP binds NIK and IKK-beta (IKBKB) and plays a role in the neuronal NF-kappa-B signaling pathway. The deduced 1,246-amino acid protein has a calculated molecular mass of 139.4 kD and shares 80 to 90% homology with the corresponding rodent sequences.
Trappc9 immunoreactivity was widespread in the cytoplasm, without specific localization to any particular organelle, and was not found in the nucleus. In 11.5-week human embryonic brain, there was higher expression in the developing cortical plate compared to the ventricular zone, indicating higher expression in postmitotic neurons than in progenitor cells.Trappc9 was found in neurons of the cerebral cortex, hippocampus, and deep gray matter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 9 (TRAPPC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 9 (TRAPPC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 9 (TRAPPC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 9 (TRAPPC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 9 (TRAPPC9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 9 (TRAPPC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 9 (TRAPPC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 9 (TRAPPC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 9 (TRAPPC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 9 (TRAPPC9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 9 (TRAPPC9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 9 (TRAPPC9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 9 (TRAPPC9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 9 (TRAPPC9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 9 (TRAPPC9) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene."Cancer Cell 3:297-302(2003) [PubMed] [Europe PMC] [Abstract]
  6. "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation."J. Biol. Chem. 280:29233-29241(2005) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly."Am. J. Hum. Genet. 85:897-902(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-beta-binding protein, in nonsyndromic autosomal-recessive mental retardation."Am. J. Hum. Genet. 85:909-915(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]