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Trafficking Protein Particle Complex 3 (TRAPPC3)

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BET3

Trafficking Protein Particle Complex 3 (TRAPPC3)
CCC F827
HGNC 19942
MGI 1351486
PubMed 8619474
RGD 1309135
UniProt O43617
Wiki TRAPPC3
TRAPPC3 is a component of the TRAPP complex, which is involved in tethering of transport vesicles to the cis-Golgi membrane.TRAPPC3 contains 180 amino acids. Bet3 expression in all mouse tissues examined. Western blot analysis of fractionated rat liver showed that most Bet3 was present in the cytosolic fraction, with a lesser amount in the Golgi-enriched membrane fraction.Cytosol depleted of Bet3 was also defective in this transport and could be rescued by recombinant Bet3. Bet3 acted after coat protein II (COPII) but before Rab1, alpha-Snap (NAPA), and the EGTA-sensitive stage during ER-Golgi transport.Both wildtype yeast Bet3 and mutant yeast Bet3 lacking palmitoylation rescued cell viability in Bet3-deleted yeast, suggesting that palmitoylation is not required for cell viability.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 3 (TRAPPC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 3 (TRAPPC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 3 (TRAPPC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 3 (TRAPPC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 3 (TRAPPC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 3 (TRAPPC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 3 (TRAPPC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 3 (TRAPPC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 3 (TRAPPC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 3 (TRAPPC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Trafficking Protein Particle Complex 3 (TRAPPC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Trafficking Protein Particle Complex 3 (TRAPPC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Trafficking Protein Particle Complex 3 (TRAPPC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Trafficking Protein Particle Complex 3 (TRAPPC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trafficking Protein Particle Complex 3 (TRAPPC3) ELISA Kit Customized Service Offer
  1. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract]
  6. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization."EMBO J. 24:875-884(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p."Traffic 6:1183-1195(2005) [PubMed] [Europe PMC] [Abstract]