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Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7)

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CHAK; CHAK1; LTRPC7; TRP-PLIK; Channel-kinase 1; Long transient receptor potential channel 7

Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7)
CCC F837
HGNC 17994
MGI 1929996
PubMed 21290295
RGD 620053
UniProt Q96QT4
Wiki TRPM7
TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.The interaction of PLIK with PLCB1 was confirmed by coimmunoprecipitation of expressed proteins in CHO-K1 cells. Northern blot analysis revealed an approximately 8-kb transcript in brain and skeletal muscle, with stronger signals in kidney, heart, liver, and spleen, consistent with the 7,105-bp transcript size for TRP-PLIK. A hemagglutinin-tagged TRP-PLIK protein was found to be membrane bound.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Polyclonal Antibody Customized Service Offer
Assay Kits SEF837Mu ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF837Ra01 Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF837Ra01 Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) WB; IHC; ICC; IP.
MAF837Ra21 Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) WB; IHC; ICC; IP.
Assay Kits SEF837Ra ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability."Nature 411:590-595(2001) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNature 412:660-660(2001)
  3. "Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel."J. Biol. Chem. 279:3708-3716(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7."Cell 114:191-200(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of annexin I by TRPM7 channel-kinase."J. Biol. Chem. 279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia."Proc. Natl. Acad. Sci. U.S.A. 101:2894-2899(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis."Nat. Cell Biol. 16:55-65(2014) [PubMed] [Europe PMC] [Abstract]
  13. "A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders."Proc. Natl. Acad. Sci. U.S.A. 102:11510-11515(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]