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Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1)

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TRP1; HTRP-1; Transient receptor protein 1

Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1)
CCC F841
HGNC 12333
MGI 109528
PubMed 23283340
RGD 619783
UniProt P48995
Wiki TRPC1
TRPC1 belongs to the transient receptor potential (TRP) superfamily of cation channels. TRP cation channels are involved in diverse physiologic processes, including receptor- and store-operated Ca(2+) entry, mineral absorption, and cell death. They also function as sensors for pain, heat, cold, sound, stretch, and osmotic changes.
TRPC1 showed 38 to 40% amino acid identity with Drosophila trp and trpl. Northern blot analysis revealed that the predicted 810-amino acid protein is transcribed as a 5.4-kb mRNA at high levels in human fetal and adult brain, in adult heart, testes, and ovary, and at lower levels in fetal liver and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 1 (TRPC1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene."FEBS Lett. 373:193-198(1995) [PubMed] [Europe PMC] [Abstract]
  2. "TRPC1, a human homolog of a Drosophila store-operated channel."Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion."Neuron 16:1189-1196(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains."J. Biol. Chem. 275:11934-11942(2000) [PubMed] [Europe PMC] [Abstract]
  6. "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells."Circ. Res. 88:84-87(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Subunit composition of mammalian transient receptor potential channels in living cells."Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells."J. Biol. Chem. 279:20941-20949(2004) [PubMed] [Europe PMC] [Abstract]
  9. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
  10. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening."Neuron 64:471-483(2009) [PubMed] [Europe PMC] [Abstract]