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Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3)

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TRP3; Transient receptor protein 3

Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3)
CCC F843
HGNC 12335
MGI 109526
PubMed 21321808
RGD 61973
UniProt Q13507
Wiki TRPC3
The Drosophila trp (transient receptor potential) and trpl (trp-like) genes encode plasma membrane cation channels that, as Zhu et al. (1996) state, may allow calcium influx in non-excitable cells in response to depletion of intracellular calcium pools, a process referred to as capacitative calcium entry (CCE), as part of the phototransduction process.
The predicted 848-amino acid human TRP3 protein is transcribed as an approximately 4-kb message predominantly in brain, and at much lower levels in several other tissues. Berg et al. (1997) stated that TRPC3 is expressed in megakaryocytic cell lines and therefore may play a role in calcium homeostasis in megakaryocytes and platelets.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 3 (TRPC3) ELISA Kit Customized Service Offer
  1. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Coassembly of TRP and TRPL produces a distinct store-operated conductance."Cell 89:1155-1164(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel."Proc. Natl. Acad. Sci. U.S.A. 102:3307-3311(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TRPC1, a human homolog of a Drosophila store-operated channel."Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry."J. Biol. Chem. 273:8675-8679(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry."J. Biol. Chem. 273:133-142(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Functional interaction between InsP3 receptors and store-operated Htrp3 channels."Nature 396:478-482(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry."Proc. Natl. Acad. Sci. U.S.A. 96:14955-14960(1999) [PubMed] [Europe PMC] [Abstract]
  12. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
  13. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
  14. "S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle."Biochem. J. 427:125-134(2010) [PubMed] [Europe PMC] [Abstract]
  15. "The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas."J. Mol. Biol. 367:373-383(2007) [PubMed] [Europe PMC] [Abstract]