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Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)

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FSGS2; TRP6; Transient receptor protein 6

Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6)
CCC F846
HGNC 12338
MGI 109523
PubMed 23045603
RGD 619788
UniProt Q9Y210
Wiki TRPC6
TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin. These compounds are inhibitors of the reuptake of serotonin, norepinephrine (noradrenaline) and epinephrine (adrenaline), dopamine, gamma-aminobutyric acid (GABA), and glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of calcium (Ca2+) and sodium (Na+) into the cell, which results in the reuptake inhibition.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF846Hu01 Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF846Hu21 Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) WB; IHC; ICC; IP.
PAF846Hu01 Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) WB; IHC; ICC; IP.
Assay Kits SEF846Hu ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily C, Member 6 (TRPC6) ELISA Kit Customized Service Offer
  1. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22."Cytogenet. Cell Genet. 83:46-47(1998) [PubMed] [Europe PMC] [Abstract]
  3. "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells."J. Biol. Chem. 275:23965-23972(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity."J. Biol. Chem. 278:47842-47852(2003) [PubMed] [Europe PMC] [Abstract]
  6. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
  7. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function."Nat. Genet. 37:739-744(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis."Science 308:1801-1804(2005) [PubMed] [Europe PMC] [Abstract]
  11. "TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype."Clin. J. Am. Soc. Nephrol. 6:1626-1634(2011) [PubMed] [Europe PMC] [Abstract]